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March 27, 2026Kidney International Reports0 citationsOpen Access

Wcn26-4466 Polycystin-1 and Polycystin-2 Function Synergistically in Fission Yeast

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TKTakayuki KoyanoShigei Medical Research InstituteKOKaori OnishiShigei Medical Research InstituteMMMakoto MatsuyamaShigei Medical Research Institute

Key Points

  • This research aims to explore how polycystin-1 and polycystin-2 work together in fission yeast and their relevance to kidney disease.
  • Utilized fission yeast as a model system to study polycystins.
  • Analyzed the effects of polycystin gene deletions on yeast viability.
  • Investigated the interactions and functions of polycystin proteins.
  • Deletion of the Pkd2 gene in fission yeast resulted in lethality.
  • Findings indicate that polycystins function synergistically in cellular processes.
  • Insights contribute to the understanding of polycystin roles in autosomal dominant polycystic kidney disease.

Abstract

Mutations in polycystins cause to autosomal dominant polycystic kidney disease (ADPKD), the most common genetic inheritant kidney disease. Although the functions of polycystins are critical to ADPKD progression, the details are still under debate. Here, we analyzed the fundamental functions of polycystins using a novel model system based on fission yeast. Fission yeast has a putative polycystin protein, Pkd2, whose gene deletion led to lethality.

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Cite This Study

Koyano et al. (2026) studied this question.

synapsesocial.com/papers/69c6207d15a0a509bde18efdhttps://doi.org/10.1016/j.ekir.2026.105120
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polycystin-2 Mediated Calcium Signalling in the Dictyostelium Model for Autosomal Dominant Polycystic Kidney Disease2024
  2. 2Disruption of Polycystin Ciliary Localization and Channel Function by Autosomal Dominant Polycystic Kidney Disease–Causing Polycystin-1 Variants2026 · 2 citations
  3. 3Mechanistic Insights into the Pathogenesis of Polycystic Kidney Disease2025 · 15 citations
  4. 4Modulation of cyst growth in autosomal dominant polycystic kidney disease: mechanistic insights and therapeutic opportunities2026
  5. 5The Link between Autosomal Dominant Polycystic Kidney Disease and Chromosomal Instability: Exploring the Relationship2024 · 2 citations