Wcn26-9397 Targeting Ppp1r3g to Protect Against Necroptosis in Renal Transplantation

Graft dysfunction, frequently resulting from injury sustained during transplantation, remains a common complication in kidney transplants. Renal cell death is a major driver of this injury and dysfunction, with necroptosis—regulated by receptor-interacting protein kinase 1 (RIPK1)—emerging as a critical mechanism. Protein phosphatase 1 regulatory subunit 3G (PPP1R3G), known to interact with protein phosphatase 1γ (PP1γ) in modulating kinase activity, has an unclear role in RIPK1 activation and tubular cell death.