Background: Insulin resistance (IR) constitutes a vital pathophysiological marker of type 2 diabetes mellitus (T2DM) and metabolic syndrome, playing a contributory role in various cardiometabolic disorders. The triglyceride-glucose index (TyG index) is emerging as a novel indicator of IR. Objectives: The study’s objectives included examining the relationship of TyG index with waist circumference (WC), glycemic control and macrovascular and microvascular complications in T2DM patients. Methods: The research was conducted as an observational and cross-sectional study over 6 months. Data analysis involved standard statistical methods. Results: Hundred patients were examined, and data showed a mean age of 52.27 ± 9.95 years, 60 men, and 40 women. The average duration of T2DM was 7.19 ± 6.65 years. In total, 26% and 55% of patients suffered from one or more macrovascular and microvascular complications, respectively. The average body mass index was 29.2 ± 4.1 kg/m 2 and WC was 91.2 ± 5.1 cm. Poor glycemic control was reflected by HbA1c of 8.89% ±1.19%. The mean TyG index was 5.1 ± 0.25. Positive associations were obtained between TyG index and WC, waist-height ratio and HbA1c. TyG index was significantly higher in those with various diabetic complications, except for neuropathy. Conclusion: TyG index correlates strongly with waist size and glycemic control. This simple marker could complement existing methods in evaluating and monitoring the risk of future cardiovascular morbidity in diabetes.
Gupta et al. (Thu,) studied this question.