What question did this study set out to answer?

To investigate the role of CST1 in cholangiocarcinoma growth and metastasis, including its prognostic significance.

March 27, 2026Cell Death DiscoveryOpen Access

NFATC2-mediated CST1 upregulation drives cholangiocarcinoma growth and metastasis

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Integrated analysis reveals CST1 upregulation promotes cholangiocarcinoma aggressiveness, suggesting new therapeutic avenues.

To investigate the role of CST1 in cholangiocarcinoma growth and metastasis, including its prognostic significance.
Evaluated public transcriptomic datasets and a local validation cohort for CST1 expression.
Conducted gain- and loss-of-function experiments in HuCCT1 and RBE cell lines.
Used murine models for orthotopic liver implantation and pulmonary metastasis studies.
Performed multi-omics profiling and survival analysis to assess prognostic significance.
CST1 was found to be significantly upregulated in cholangiocarcinoma tissues.
Increased CST1 expression correlated with poor patient prognosis.
Overexpression of CST1 enhanced cell proliferation, invasion, and metastasis.
CST1 overexpression decreased senescence markers and was associated with SOX4 stabilization.

Zhao et al. (2026) studied this question.

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