Model-based evaluation demonstrates multitarget stool DNA testing is more effective in colorectal cancer screening, suggesting broader adoption may improve early detection.
With real-world adherence, screening with triennial ng mt-sDNA demonstrates superior cumulative effectiveness compared with decennial colonoscopy, driven by higher adherence and favorable longitudinal performance. These findings support expanded use of noninvasive stool-based screening to reduce CRC mortality and alleviate colonoscopy capacity constraints. Broader adoption of ng mt-sDNA may enhance population-level CRC prevention by increasing participation and improving early detection.
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Dore et al. (2026) studied this question.
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