Why the study?
Does Sglt2 deletion reduce cardiorenal damage and improve survival in Dahl salt-sensitive hypertensive rats?
Observational
Does Sglt2 deletion reduce cardiorenal damage and improve survival in Dahl salt-sensitive hypertensive rats?
Sglt2 deletion in a hypertensive rat model attenuates cardiorenal damage but does not improve survival or prevent stroke, suggesting that hypertension remains the dominant risk factor for stroke.
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Caution against over-reliance on SGLT2 inhibition for survival in hypertension; reinforces hypertension as dominant risk factor for stroke.
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Ito et al. (2026) conducted an observational in Renal disease. Renal magnetic resonance imaging (DTI) was evaluated on Medullary DTI parameters (MD, AD, RD), eGFR, and complement C3.
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