What question did this study set out to answer?

This review aims to critically analyze methods for assessing and adjusting publication bias in clinical meta-analyses.

March 28, 2026Korean journal of anesthesiologyOpen Access

Correcting what cannot be corrected: rethinking publication bias analysis methods in clinical meta-analyses

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This review aims to critically analyze methods for assessing and adjusting publication bias in clinical meta-analyses.
Reviewed classical methods for detecting publication bias, such as funnel plots and small-study effects.
Examined adjustment methods, including trim-and-fill and regression-based approaches.
Illustrated how different methods yield divergent results using a worked example.
Demonstrated that statistical adjustments cannot recover lost information due to selective publication.
Highlighted common misuses of publication bias methods and their implications for evidence interpretation.
Proposed a framework for evaluating publication bias adjustment methods.

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Implication

This review assesses and critiques publication bias analysis methods in meta-analyses, suggesting improvements and implications for clinical conclusions.

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Hyun Kang (2026) studied this question.

synapsesocial.com/papers/69c770418bbfbc51511e082a https://doi.org/10.4097/kja.26020

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Implication

This review assesses and critiques publication bias analysis methods in meta-analyses, suggesting improvements and implications for clinical conclusions.

Correcting what cannot be corrected: rethinking publication bias analysis methods in clinical meta-analyses

Key Points

Discussion

Implication

Cite This Study

Correcting what cannot be corrected: rethinking publication bias analysis methods in clinical meta-analyses

Key Points

Discussion

Implication

Cite This Study

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