IgG4-related disease, he received immunosuppressive therapy, antibiotics, and antifungal prophylaxis.He improved with increased urine output and decreased creatinine, achieving full recovery.This case highlights the importance of a multifaceted approach in managing complex autoimmune conditions.Results: AAV involves necrotizing vasculitis with ANCAs, affecting small to medium vessels, and manifests with glomerulonephritis and systemic symptoms.IgG4-RD is marked fibro-inflammatory lesions with IgG4-positive plasma cells and storiform fibrosis.Renal involvement in IgG4-RD often presents as tubulointerstitial nephritis.Our patient showed features of both conditions, confirmed by biopsy.Treatment with corticosteroids and cyclophosphamide improved renal function and systemic symptoms, highlighting the need for integrated diagnosis and therapy in overlap syndromes. Conclusion:The overlap of ANCA-associated vasculitis and IgG4related disease is rare but crucial to recognize for optimal treatment.Research into shared mechanisms will improve understanding and management of autoimmune diseases.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.
Truong et al. (Wed,) studied this question.