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March 25, 2026Kidney International ReportsOpen Access

WCN26-8197 BUDESONIDE MODULATES B- AND T-CELL IMMUNITY IN PEYER'S PATCHES: IMPLICATIONS FOR IgA NEPHROPATHY

Roza Ghotbi Jens Kristensen Krassimir Mitchev Johan Häggblad

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Key Points

This research investigates how budesonide influences B- and T-cell immune responses in Peyer's patches and its potential implications for IgA nephropathy.
Examined immune cell responses in Peyer's patches of treated mice
Assessed complement activity in response to budesonide
Analyzed the impact of gene transduction on immune regulation
Budesonide altered B- and T-cell activity in Peyer's patches
Complement activity changes were noted in response to treatment
Potential benefits of these findings for IgA nephropathy management were identified

Implication

Findings show that budesonide influences immune function in Peyer’s patches, suggesting benefits for IgA nephropathy.

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Cite This Study

Ghotbi et al. (2026) studied this question.

synapsesocial.com/papers/69c770888bbfbc51511e0a47 https://doi.org/10.1016/j.ekir.2026.105070

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