WCN26-5302 ROS-Responsive Nanoparticles Mediate Rhein Release to Reprogram Macrophages for Attenuating Acute Kidney Injury

Introduction: Acute kidney injury is a condition that is often encountered in hospitalized patients, affecting 1 in 5 hospitalized patients and may lead to serious complication from progression to endstage renal disease to death.Its management become challenging, especially in hospitals with limited facilities and financial support from national health insurance, especially in developing countries Methods: This is a retrospective cross-sectional study with 251 adult patients were observed from January to December 2024.AKI was defining according to serum creatinine levels as proposed by KDIGO 2024.This study included all patients aged >18 years who were admitted to the hospital, diagnosed with AKI at admission and were died <48 hours.Patients with incomplete medical records and those with no reported creatinine levels during their stay, pregnant women and kidney transplant patients were excluded.An analysis of bivariate relationships were conducted using SPSS v25.0 between age > 60 years, genders, DM, CKD, CHF, hypertension, post-renal obstruction, infection, sepsis, cardiac arrest and encephalopathy hepaticum.The risk factors of mortality in patients with AKI was compared using the chi-squared test and among significant variables, logistic regression analysis was performed Results: The prevalence mortality of AKI patient in Moewardi Hospital during 2024 was 30.46% (251 out of 824).The mean age was 60.27 13.5 years, while mean creatinine serum at admission was 4.28 3.07.Males gender were the majority of the patients (59,8%) as well as age > 60 years (51,4%).Factors related to increased mortality in multivariate analysis were DM (OR 14,552; CI 95% 1,032), hypertension (OR 0,051; CI 95% 0,007-0,396), CHF (OR 30,433; CI 95% 2,641), infection (OR 7,148; CI 95% 1,065), post-renal obstruction (OR 7,006; CI 95% 1,094-44,847) and sepsis (OR 0,12; CI 95% 0,025-0,575).Conclusion: DM, hypertension, CHF, infection, post-renal obstruction and sepsis are factors that significantly associated with increased mortality of AKI in hospitalized patients.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.