Research uncovers how miRNAs are downregulated via lncRNA interactions, indicating new regulatory pathways.
MicroRNAs (miRNAs) regulate gene expression by recruiting Argonaute (AGO) proteins to specific targets, forming the microRNA (miRNA)-induced silencing complex (miRISC). In this issue of Genes & Development , Grimme and colleagues (doi:10.1101/gad.353314.125) determine how a family of related miRNAs is coordinately downregulated through limited base-pairing interactions with a long noncoding RNA (lncRNA). The lncRNA serves as a potent trigger to induce target-mediated miRNA decay (TDMD) despite supporting a looser pairing architecture with the miRNAs than typically needed.
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Amy E. Pasquinelli (2026) studied this question.
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