Demonstrates matrine improves bile acid metabolism in colitis, suggesting therapeutic potential for inflammatory bowel disease.
This study is the first to comprehensively demonstrate that matrine directly targets the JAK2/STAT3 signaling axis to restore bile acid homeostasis and suppress inflammation in experimental colitis with validation in human UC patients, providing novel mechanistic and translational insight into how matrine may benefit colitis.
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Jiang et al. (2026) studied this question.
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