What does this research mean for the field?

Mandibular advancement with a Twin Block appliance induces a significant early increase in salivary IGF-1 levels within 7-10 days, followed by a peak in BALP levels at 6-10 weeks, indicating their involvement in the biochemical response to the therapy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The research aims to explore changes in salivary IGF-1 and BALP levels during treatment with a Twin Block appliance.

March 28, 2026

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Salivary insulin-like growth factor-1 (IGF-1) and bone alkaline phosphatase (BALP) levels during mandibular advancement with Twin Block appliance: A longitudinal study

TTTulika TripathiMaulana Azad Institute of Dental Sciences NSNavneet SinghUniversity College of Medical Sciences VGVeena GVMaulana Azad Institute of Dental Sciences

Key Points

The research aims to explore changes in salivary IGF-1 and BALP levels during treatment with a Twin Block appliance.
Conducted a longitudinal study measuring salivary IGF-1 and BALP levels.
Monitored changes over a period of 10 weeks during Twin Block appliance therapy.
Salivary IGF-1 levels increased significantly within 7-10 days.
BALP levels peaked between 6-10 weeks of treatment.
Findings suggest that IGF-1 and BALP may play a key role in the body's response to the appliance.

Abstract

The study demonstrated a significant increase in salivary IGF-1 levels within 7-10 days, with BALP levels peaking at 6-10 weeks. These findings suggest a potential role of IGF-1 and BALP in the biochemical response to Twin Block appliance therapy.

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View Full Paper

Salivary insulin-like growth factor-1 (IGF-1) and bone alkaline phosphatase (BALP) levels during mandibular advancement with Twin Block appliance: A longitudinal study

Key Points

Abstract

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