Key result
Every unit increase in TyG-WHtR was significantly associated with an increased risk of venous thromboembolism (HR 1.35; 95% CI 1.31-1.39; P<0.001), an effect partially mediated by inflammation.
Why the study?
Are elevated triglyceride-glucose related indices associated with an increased risk of incident venous thromboembolism?
Cohort (n=502,131)
Yes
Are elevated triglyceride-glucose related indices associated with an increased risk of incident venous thromboembolism?
Hazard Ratio: 1.35 (95% CI 1.31–1.39)
p-value: p=< 0.001
Triglyceride-glucose related indices incorporating obesity measures are significantly associated with an increased risk of incident venous thromboembolism, an effect partially mediated by inflammation.
Recently, the triglyceride-glucose (TyG) index and its related indices (TyG-BMI, TyG-WC, and TyG-WHtR) have been regarded as reliable markers of insulin resistance, which has been associated with the risk of various cardiovascular diseases. However, the influence of TyG-related indices on venous thromboembolism (VTE) remains unknown. We explored the relation of TyG and related indices with new-onset VTE in the current study. In the current study, a total of 502,131 participants were recruited between 2006 and 2010. The primary study outcome was the incidence of VTE, including deep vein thrombosis (DVT) and pulmonary embolism (PE). Cox hazard and restricted cubic spline (RCS) regressions were performed to investigate the relationship between TyG-related indices and the risk of VTE. Mediation analysis was performed to investigate whether C reactive protein (CRP) mediated the association between TyG-related index and VTE. During the follow-up period, 13,347 (3.22%) participants developed VTE. TyG index and its related indices were significantly associated with the incidence of VTE. After adjusting for potential confounders, an increased risk of VTE was associated with every unit increase in TyG-WHtR (HR: 1.35, 95% CI: 1.31–1.39, P < 0.001, E value = 2.04), as well as with every 100 unit increase in TyG-BMI (HR: 1.70, 95% CI: 1.63–1.76, P < 0.001, E value = 2.79) and TyG-WC (HR: 1.24, 95% CI: 1.22–1.26, P < 0.001, E value = 1.79), while not associated with every unit increase in TyG (HR: 1.02, 95% CI: 0.97–1.07, p = 0.41). According to RCS analysis, TyG-WHtR, TyG-BMI, and TyG-WC were non-linear associated with VTE. Mediation analysis showed that CRP played a statistically significant mediating role in the relation of TyG-WHtR (HR: 1.02, 95% CI: 1.02–1.02, P < 0.001), TyG-BMI (HR: 1.03, 95% CI: 1.03–1.04, P < 0.001) and TyG-WC (HR: 1.01, 95% CI: 1.01–1.01, P < 0.001) with the VTE risk. TyG-WHtR, TyG-BMI, and TyG-WC are significantly associated with the incidence of VTE. Our findings suggest that part of TyG related indices in the risk of VTE is potentially mediated by inflammation.
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Wang et al. (2026) conducted a cohort in Venous thromboembolism (n=502,131). Triglyceride-glucose (TyG) related indices vs. Lower levels (per unit increase) was evaluated on Incidence of VTE, including deep vein thrombosis (DVT) and pulmonary embolism (PE) (HR 1.35, 95% CI 1.31-1.39, p=< 0.001). Every unit increase in TyG-WHtR was significantly associated with an increased risk of venous thromboembolism (HR 1.35; 95% CI 1.31-1.39; P<0.001), an effect partially mediated by inflammation.
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