What question did this study set out to answer?

This study investigates the relationship between triglyceride-glucose indices and the incidence of venous thromboembolism.

March 28, 2026Open Access

Association of triglyceride-glucose related indices with the incidence of venous thromboembolism: a nationwide prospective cohort study based on the UK Biobank

Puntos clave

This study investigates the relationship between triglyceride-glucose indices and the incidence of venous thromboembolism.
Nationwide prospective cohort study using UK Biobank data
Included 502,131 participants recruited from 2006 to 2010
Analyzed incidence of venous thromboembolism using Cox regression
Performed mediation analysis to assess C reactive protein's role
Examined non-linear associations using restricted cubic splines
13,347 participants developed venous thromboembolism during follow-up (3.22%)
TyG-WHtR, TyG-BMI, and TyG-WC significantly associated with increased VTE risk
Every unit increase in TyG-WHtR increased VTE risk by 35%
Every 100 unit increase in TyG-BMI increased VTE risk by 70%
C reactive protein significantly mediated the association with VTE risk

Resumen

Recently, the triglyceride-glucose (TyG) index and its related indices (TyG-BMI, TyG-WC, and TyG-WHtR) have been regarded as reliable markers of insulin resistance, which has been associated with the risk of various cardiovascular diseases. However, the influence of TyG-related indices on venous thromboembolism (VTE) remains unknown. We explored the relation of TyG and related indices with new-onset VTE in the current study. In the current study, a total of 502,131 participants were recruited between 2006 and 2010. The primary study outcome was the incidence of VTE, including deep vein thrombosis (DVT) and pulmonary embolism (PE). Cox hazard and restricted cubic spline (RCS) regressions were performed to investigate the relationship between TyG-related indices and the risk of VTE. Mediation analysis was performed to investigate whether C reactive protein (CRP) mediated the association between TyG-related index and VTE. During the follow-up period, 13,347 (3.22%) participants developed VTE. TyG index and its related indices were significantly associated with the incidence of VTE. After adjusting for potential confounders, an increased risk of VTE was associated with every unit increase in TyG-WHtR (HR: 1.35, 95% CI: 1.31–1.39, P < 0.001, E value = 2.04), as well as with every 100 unit increase in TyG-BMI (HR: 1.70, 95% CI: 1.63–1.76, P < 0.001, E value = 2.79) and TyG-WC (HR: 1.24, 95% CI: 1.22–1.26, P < 0.001, E value = 1.79), while not associated with every unit increase in TyG (HR: 1.02, 95% CI: 0.97–1.07, p = 0.41). According to RCS analysis, TyG-WHtR, TyG-BMI, and TyG-WC were non-linear associated with VTE. Mediation analysis showed that CRP played a statistically significant mediating role in the relation of TyG-WHtR (HR: 1.02, 95% CI: 1.02–1.02, P < 0.001), TyG-BMI (HR: 1.03, 95% CI: 1.03–1.04, P < 0.001) and TyG-WC (HR: 1.01, 95% CI: 1.01–1.01, P < 0.001) with the VTE risk. TyG-WHtR, TyG-BMI, and TyG-WC are significantly associated with the incidence of VTE. Our findings suggest that part of TyG related indices in the risk of VTE is potentially mediated by inflammation.

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Cite This Study

Wang et al. (Thu,) studied this question.

synapsesocial.com/papers/69c771508bbfbc51511e12a2 https://doi.org/https://doi.org/10.1186/s12872-026-05735-7

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