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March 28, 2026Histopathology2 citationsOpen Access

Clinicopathological and transcriptomic profiles of 101 patients with diffuse large B‐cell lymphoma/high‐grade B‐cell lymphoma with double‐hit MYC and BCL2 or BCL6 and triple hit

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MMMasashi MiyaokaJCJoaquim Sempere CarrerasYKYara Yukie Kikuti

Key Points

  • The aim is to analyze clinicopathological and transcriptomic profiles in patients with various diffuse large B-cell lymphoma subtypes.
  • Characterized 101 patients with diffuse large B-cell lymphoma/high-grade B-cell lymphoma.
  • Separated patients into groups based on MYC, BCL2, and BCL6 expression.
  • Conducted survival analysis for each lymphoma subtype.
  • Identified distinct survival outcomes between DLBCL/HGBCL-DH-BCL6 and DLBCL/HGBCL-DH-BCL2.
  • Noted that DLBCL/HGBCL-TH has the worst survival rates.
  • Recommended testing for all three genes in the diagnosis of DLBCL/HGBCL.

Abstract

DLBCL/HGBCL-DH-BCL6 differs from the DLBCL/HGBCL-DH-BCL2, and the DLBCL/HGBCL-TH is associated with the worst survival. Analysis of all three genes of MYC, BCL2 and BCL6 is recommended in the context of DLBCL/HGBCL diagnosis.

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Cite This Study

Miyaoka et al. (2026) studied this question.

synapsesocial.com/papers/69c771688bbfbc51511e15e4https://doi.org/10.1111/his.70117
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