Clinicopathological and transcriptomic profiles of 101 patients with diffuse large B‐cell lymphoma/high‐grade B‐cell lymphoma with double‐hit MYC and BCL2 or BCL6 and triple hit

Key Points

The aim is to analyze clinicopathological and transcriptomic profiles in patients with various diffuse large B-cell lymphoma subtypes.
Characterized 101 patients with diffuse large B-cell lymphoma/high-grade B-cell lymphoma.
Separated patients into groups based on MYC, BCL2, and BCL6 expression.
Conducted survival analysis for each lymphoma subtype.
Identified distinct survival outcomes between DLBCL/HGBCL-DH-BCL6 and DLBCL/HGBCL-DH-BCL2.
Noted that DLBCL/HGBCL-TH has the worst survival rates.
Recommended testing for all three genes in the diagnosis of DLBCL/HGBCL.

Analysis of gene profiles reveals differing survival rates in patients with distinct lymphoma types, suggesting tailored approaches for treatment.

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Miyaoka et al. (2026) studied this question.

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