Novel Turn-on Fluorescent Probe for Endogenous Peroxynitrite Detection Based on Selective Oxidation of Nitrobenzoyl Formate Ester

Wen Di; Jingyue Peng; Yuanhong Li; Jin Hui; Haijun Chi; Yuxin Guo; Gonghao Lu

doi:10.1039/d6nj00010j

January 1, 2026New Journal of Chemistry

Novel Turn-on Fluorescent Probe for Endogenous Peroxynitrite Detection Based on Selective Oxidation of Nitrobenzoyl Formate Ester

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Key Points

This research aims to develop a new fluorescent probe for the specific detection of endogenous peroxynitrite.
Designed a turn-on fluorescent probe (EASHC-NO2) for detection.
Utilized intramolecular charge transfer (ICT) mechanism.
Focused on selective oxidation of nitrobenzoyl formate ester for sensing.
Successfully demonstrated fluorescence activation upon peroxynitrite presence.
Proved effective detection of peroxynitrite in biological samples.
Showed high selectivity and sensitivity towards peroxynitrite.

Implication

A novel fluorescent probe detects peroxynitrite in biological systems, implying potential for medical diagnostics.

Abstract

A turn-on fluorescent probe (EASHC-NO2) is designed for endogenous peroxynitrite (ONOO⁻) detection. The probe contains a fluorophore with intramolecular charge transfer (ICT) effect and a selective sensing site containing nitro...

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Cite This Study

Di et al. (2026) studied this question.

synapsesocial.com/papers/69c771838bbfbc51511e1665 https://doi.org/10.1039/d6nj00010j

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Novel Turn-on Fluorescent Probe for Endogenous Peroxynitrite Detection Based on Selective Oxidation of Nitrobenzoyl Formate Ester

Key Points

Implication

Abstract

Discussion

Cite This Study

Novel Turn-on Fluorescent Probe for Endogenous Peroxynitrite Detection Based on Selective Oxidation of Nitrobenzoyl Formate Ester

Key Points

Implication

Abstract

Discussion

Cite This Study

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