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March 26, 2026Natural Product Research

Design, synthesis and anticancer evaluation of chrysin-1,3,5-triazine derivatives

Rongbin Wei Cong Qi XuanYi Xue Luyao Wang Yamin Ding Yuanfen Zhai Dahua Shi Ming Hu

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Key Points

The aim is to design and evaluate chrysin-based triazine derivatives for their anticancer effects, particularly in breast cancer.
Synthesized multiple chrysin-based triazine compounds.
Assessed anti-proliferative activity against breast cancer cell lines.
Evaluated the impact on apoptosis and related molecular pathways.
RQ-6 showed significant inhibition of breast cancer cell proliferation and induced apoptosis.
Modulated apoptosis-related protein levels including caspase-3 and p53.
Activated key molecular pathways involved in cancer cell death.

Implication

In vitro evaluation demonstrates anticancer efficacy of chrysin derivatives in breast cancer, suggesting therapeutic potential.

Discussion

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Cite This Study

Wei et al. (2026) studied this question.

synapsesocial.com/papers/69c771838bbfbc51511e1692 https://doi.org/10.1080/14786419.2026.2647366

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