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This mini-review aims to explore the molecular mechanisms by which extracellular vesicles function as carriers in cancer therapy.

March 28, 2026BiocellOpen Access

Extracellular Vesicles as Promising Carriers in Cancer Therapy: Molecular Mechanisms of Biogenesis, Targeting, and Intracellular Action

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Mini-review illustrates how extracellular vesicles improve drug delivery in cancer, indicating significant therapeutic potential.

This mini-review aims to explore the molecular mechanisms by which extracellular vesicles function as carriers in cancer therapy.
Reviewed literature on extracellular vesicles in cancer therapy
Analyzed biogenesis and cargo selection processes
Examined surface tropism and internalization pathways
Summarized engineering advances for drug and RNA delivery
Extracellular vesicles demonstrate biocompatibility and stability in biological fluids
Elective cargo delivery enhances therapeutic precision
Regulated sorting and targeting processes improve specificity in tumor cells
Engineering advancements position EVs as viable drug delivery platforms

Montefusco et al. (2026) studied this question.

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