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March 28, 2026Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi DergisiOpen Access

Investigation of Cytogenetic Abnormalities in Newly Diagnosed Multiple Myeloma Patients by Optical Genome Mapping

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Authors

DGDeniz GüneyIstanbul UniversityATAyşe Bayrak TokaçIstanbul UniversityAAAynur Dağlar AdayIstanbul University

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Implication

Analysis identifies cytogenetic abnormalities in multiple myeloma, suggesting enhanced diagnostic potential of optical genome mapping.

Key Points

  • The study aims to explore the cytogenetic abnormalities in newly diagnosed multiple myeloma patients using optical genome mapping.
  • Conducted on five newly diagnosed multiple myeloma patients.
  • Bone marrow samples collected for analysis.
  • Optical genome mapping and FISH techniques utilized.
  • Flow cytometry used to isolate plasma cells.
  • Patient diagnostics revealed various chromosomal abnormalities through FISH and OGM.
  • OGM identified multiple aneuploidies, deletions, and duplications not detected by FISH.
  • Overall, OGM provided more comprehensive karyotypic classifications compared to traditional methods.

Cite This Study

Güney et al. (2026) studied this question.

synapsesocial.com/papers/69c771838bbfbc51511e17d6https://doi.org/10.26650/iuitfd.1808157
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