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Comparative Efficacy of Bulevirtide, Interferons, and Nucleos(t)ide Analogs for Chronic Hepatitis Delta: A Systematic Review and Network Meta‐Analysis

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This analysis aims to compare the efficacy of bulevirtide, interferons, and nucleos(t)ide analogs for treating chronic hepatitis D.
Conducted a systematic review and network meta-analysis of existing trials.
Searched PubMed, Embase, and Cochrane for relevant studies.
Evaluated HDV RNA suppression, biochemical response, combined response, and histological improvement.
Used a frequentist random-effects model for analysis and calculated odds ratios.
Thirteen studies with 922 patients were included in the analysis.
31.8% of patients achieved a virological response at the end of treatment.
Bulevirtide monotherapy and its combinations showed significant HDV RNA suppression.
No treatment maintained significant suppression at follow-up after 24 weeks.
Biochemical response was observed in 42.7% at end of treatment, with bulevirtide combinations performing best.

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Systematic review compares efficacy of bulevirtide, interferons, and nucleos(t)ide analogs in chronic hepatitis D, suggesting potential treatments.

Karkra et al. (2026) studied this question.

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Systematic review compares efficacy of bulevirtide, interferons, and nucleos(t)ide analogs in chronic hepatitis D, suggesting potential treatments.