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March 28, 2026Genome Research

Isoform- and pathway-specific regulation of post-transcriptional RNA processing in human cells

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Authors

INIshwarya Venkata NarayananKBKaran BediBMBrian Magnuson

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Overview

Investigates RNA turnover dynamics in human cells, revealing their importance in gene expression regulation.

Key Points

  • The aim is to understand how RNA turnover dynamics regulate gene expression through different transcripts and pathways.
  • Utilized nascent RNA Bru-seq and BruChase-seq techniques across 16 human cell lines.
  • Conducted gene set enrichment analysis (GSEA) to compare RNA turnover dynamics among pathways.
  • Analyzed splicing patterns of newly synthesized transcripts.
  • RNA turnover dynamics vary significantly between different gene transcripts and RNA classes.
  • Transcripts within the same pathway show similar turnover dynamics.
  • Distinct turnover profiles are exhibited by different transcript isoforms.
  • Splicing of new transcripts occurs in a binary manner across exons.

Cite This Study

Narayanan et al. (2026) studied this question.

synapsesocial.com/papers/69c771988bbfbc51511e1931https://doi.org/10.1101/gr.280892.125
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  1. 1Isoform and pathway-specific regulation of post-transcriptional RNA processing in human cells2024
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