What question did this study set out to answer?

This research aims to develop a Radiopathomics model using ultrasound and histology imaging to predict axillary lymph node metastasis in triple-negative breast cancer.

March 28, 2026World Journal of Surgical OncologyOpen Access

Combining ultrasound and core needle histology imaging Radiopathomics model in predicting axillary lymph node metastasis in triple-negative breast cancer

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Authors

LYLi YanhuaNanchong Central Hospital TYTang YanNanchong Central Hospital LXLiu XiaolingNanchong Central Hospital

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Implication

Multicenter retrospective study predicts axillary lymph node metastasis in triple-negative breast cancer, implying better treatment planning.

Key Points

This research aims to develop a Radiopathomics model using ultrasound and histology imaging to predict axillary lymph node metastasis in triple-negative breast cancer.
Conducted a multicenter retrospective study with TNBC patients from three medical centers.
Extracted radiomic features from ultrasound images and pathomic features from core needle biopsy histology images.
Utilized the LASSO algorithm for feature selection and built the model using the XGBoost algorithm.
Evaluated model performance with metrics like AUC, accuracy, sensitivity, and specificity.
243 TNBC patients were included, with 102 showing axillary lymph node metastasis.
The AUCs for training, validation, and testing groups were 0.892, 0.848, and 0.831 respectively.
The Radiopathomics model outperformed clinical, Radiomics, and Pathomics models in predicting ALNM.

Cite This Study

Yanhua et al. (2026) studied this question.

synapsesocial.com/papers/69c771dd8bbfbc51511e1f20 https://doi.org/10.1186/s12957-026-04316-4

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Implication

Multicenter retrospective study predicts axillary lymph node metastasis in triple-negative breast cancer, implying better treatment planning.

Combining ultrasound and core needle histology imaging Radiopathomics model in predicting axillary lymph node metastasis in triple-negative breast cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Combining ultrasound and core needle histology imaging Radiopathomics model in predicting axillary lymph node metastasis in triple-negative breast cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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