Morinda lucida Leaf Metabolites Ameliorate Aluminium Chloride‐Mediated Chronic Inflammation and Modulate Proteins‐Linked to Erectile Dysfunction in Rat Testes
Investigation demonstrates Morinda lucida improves sperm morphology in rats, indicating potential for male fertility preservation.
Key Points
The research aims to assess the protective effects of Morinda lucida leaf extract against aluminium chloride-induced testicular damage and its influence on erectile dysfunction-related proteins.
Administered aluminium chloride and Morinda lucida leaf extract to male rats over 21 days.
Conducted sperm count and morphology assessments after treatment.
Analyzed myeloperoxidase activity, IL-6, TNF-α, and nitrite levels in treated vs. untreated groups.
Performed molecular docking to evaluate interactions with phosphodiesterase-5 and arginase.
Sperm count significantly decreased in rats treated with aluminium chloride alone.
Morinda lucida extract improved sperm morphology compared to untreated rats.
The leaf extract normalized elevated myeloperoxidase, IL-6, TNF-α, and nitrite levels.
Molecular docking revealed stigmasterol and oruwacin had favorable binding to target proteins.