Prospective analysis demonstrates the clinical utility of comprehensive genomic profiling in cancer therapy, suggesting increased patient treatment options.
The added value of comprehensive genomic and transcriptomic profiling (CGTP) with whole exome sequencing (WES) and whole transcriptome sequencing (WTS) as compared to conventional targeted panel-based sequencing is not well-characterized for patients with cancer. We thus sought to determine the potential clinical utility of CGTP in a prospective clinical study in patients with advanced or metastatic solid tumors. We performed WES and WTS for patients who had prior targeted panel sequencing and had no DNA alterations with approved biomarker-matched therapies. We analyzed CGTP data of 99 patients with advanced cancers across 19 solid tumor types and assessed presence of actionable DNA alterations and RNA expressions linked to approved or investigational agents. CGTP identified actionable genomic and transcriptomic alterations in 69.7% and 100% of cases, respectively. In this pilot study where CGTP was incorporated into routine care, 19.2% of patients received biomarker-matched therapy.
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Uzunparmak et al. (2026) studied this question.
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