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March 28, 2026BMC OphthalmologyOpen Access

Comparative peripheral inflammatory biomarker profiles in central and branch retinal artery occlusion: a retrospective study

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Authors

AMAl Asadi Hussein Mohammed MahdiWuhan UniversityXXXuan XiaoWuhan University

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Implication

Retrospective study compares inflammatory profiles in CRAO and BRAO, suggesting distinct systemic variations.

Key Points

  • This study aims to compare peripheral inflammatory biomarker profiles between central retinal artery occlusion and branch retinal artery occlusion.
  • Retrospective observational study of 363 RAO patients
  • Comparison of inflammatory biomarkers using independent-sample t tests and Mann–Whitney U tests
  • Sex- and age-stratified analyses to identify subgroup patterns
  • Focus on biomarkers including leukocyte count, neutrophil percentage, and lymphocyte percentage.
  • BRAO patients had higher leukocyte counts compared to CRAO (p = 0.03)
  • Lymphocyte percentages were higher in BRAO compared to CRAO (p = 0.01)
  • CRAO patients showed lower neutrophil percentages than BRAO (p = 0.01)
  • No significant difference in CRP levels between the groups, though variability was higher for CRAO
  • NLR was higher in BRAO than CRAO, indicating distinct inflammatory profiles.

Cite This Study

Mahdi et al. (2026) studied this question.

synapsesocial.com/papers/69c771f08bbfbc51511e20d2https://doi.org/10.1186/s12886-026-04715-x
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Also Consider

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  1. 1Peripheral blood transcriptomic analysis identifies potential inflammation and immune signatures for central retinal artery occlusion2024 · 6 citations
  2. 2Risk of Stroke, Myocardial Infarction, and Death After Retinal Artery Occlusion2023 · 46 citations
  3. 3Role of inflammation in previously untreated macular edema with branch retinal vein occlusion2014 · 46 citations
  4. 4Intraocular complement activation is independent of systemic complement activation and is related to macular vascular remodelling in retinal vein occlusion2024 · 5 citations