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March 28, 2026Physiological Entomology

The multifaceted effects of Melia azedarach leaf extract on Galleria mellonella : Enzymatic, histological and ultrastructural investigations

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Authors

ZEZeinab A. El‐MoatyHAHelmy A. AamerNANajla M. Albishi

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Overview

This research evaluates the insecticidal effects of Melia azedarach leaf extract on Galleria mellonella, suggesting its potential as a biocontrol agent.

Key Points

  • The research aims to assess the insecticidal potential of Melia azedarach leaf extract against Galleria mellonella larvae through various analyses.
  • Conducted phytochemical screening to determine the content of polyphenolics.
  • Performed acute toxicity assessments through ingestion to calculate LD50.
  • Evaluated midgut enzyme activities and conducted histological and ultrastructural analyses.
  • Phytochemical screening revealed high levels of phenolic and flavonoid compounds.
  • Acute toxicity showed a dose-dependent mortality rate with an LD50 of 1.39 mg g−1.
  • Sublethal exposure caused significant developmental delays and reduced pupal weight and fecundity.
  • Midgut enzyme activities declined significantly, with lysozyme activity reduced by 68.13%.
  • Histological analyses revealed extensive damage to midgut epithelial tissues.

Cite This Study

El‐Moaty et al. (2026) studied this question.

synapsesocial.com/papers/69c771f08bbfbc51511e218dhttps://doi.org/10.1111/phen.70040
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