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This study aims to identify effective strategies to combat venetoclax resistance in acute myeloid leukemia.

Bortezomib Restores Venetoclax Sensitivity in Acute Myeloid Leukemia Cell Lines with Intrinsic and Acquired Resistance

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This study aims to identify effective strategies to combat venetoclax resistance in acute myeloid leukemia.
Tested the effects of bortezomib on AML cell lines with intrinsic and acquired venetoclax resistance.
Measured apoptosis induction through combination therapies.
Analyzed the upregulation of pro-apoptotic proteins NOXA, BIM, and PUMA.
Bortezomib demonstrated potent synergy with venetoclax in inducing apoptosis across various AML cell lines.
Bortezomib was effective in resensitizing cell lines exhibiting acquired resistance to venetoclax.
Combination treatments significantly prolonged survival in mice with venetoclax-resistant AML cell lines.

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In vitro study uncovers bortezomib's role in overcoming venetoclax resistance in AML, suggesting new treatment strategies.

Li et al. (2026) studied this question.

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