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Demonstrates a green synthesis of 4-acetylcinnamic acid in water, indicating an innovative approach for undergraduates.
This paper describes the Heck synthesis of (E )-4-acetylcinnamic acid from 4-iodoacetophenone and acrylic acid under catalysis by Pd (0). Traditional Heck reaction organic solvents (acetonitrile, N-methyl-2-pyrrolidone) and base (triethylamine) are replaced by water and sodium carbonate respectively. This approach introduces fundamentals of green chemistry to undergraduates whilst highlighting current research via an industrially significant reaction.
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Cheung et al. (2007) studied this question.
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