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This work aims to evaluate the performance of a palladium-containing polymeric precatalyst in sustainable Mizoroki–Heck cross-coupling reactions.

June 17, 2026ACS OmegaOpen Access

Sustainable Mizoroki–Heck Cross-Coupling Using a Pd(II)-Polymer as Precatalyst in 1-Butanol

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Randomized trial demonstrates efficient palladium-catalyzed reactions in 1-butanol, indicating eco-friendly alternatives.

This work aims to evaluate the performance of a palladium-containing polymeric precatalyst in sustainable Mizoroki–Heck cross-coupling reactions.
Utilized Pd/PECIm as a precatalyst for the Mizoroki–Heck reaction in various solvent systems including 1-butanol.
Reactions were scaled up 50-fold to establish yield efficiency under optimized conditions.
Achieved 95% conversion to ethyl cinnamate within 1.5 hours using 0.5 mol% Pd in 1-butanol.
Demonstrated the catalyst's ability to be reused for at least five cycles with maintained performance.
Scaled-up process yielded 93% with good substrate scope, producing diverse derivatives.

Nishida et al. (2026) studied this question.

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