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March 28, 2026
Open Access
MLL-AF9 expression levels do not instruct lineage fate
EK
Emmanouil Kyrloglou
University Medical Center Groningen
MC
Marco Carretta
University Medical Center Groningen
AB
Annet Z. Brouwers-Vos
University Medical Center Groningen
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Key Points
The central aim is to investigate whether MLL-AF9 expression levels determine lineage fate in cells.
Assessment of MLL-AF9 expression levels across different cell types
Analysis of lineage differentiation outcomes
Comparative studies with control genes
No significant correlation between MLL-AF9 expression and lineage fate observed
Lineage fate determination appears to be influenced by factors other than MLL-AF9 expression
Alternative regulatory mechanisms may play a key role in lineage specification
Abstract
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MLL-AF9 expression levels do not instruct lineage fate | Synapse
Cite This Study
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Kyrloglou et al. (Thu,) studied this question.
synapsesocial.com/papers/69c772158bbfbc51511e24a2
https://doi.org/https://doi.org/10.3324/haematol.2025.300365