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March 26, 2026BiomoleculesOpen Access

Deciphering the Ubiquitin-like Code of DNA-PK: Mechanisms and Therapeutic Opportunities

Jiaqi Zhao Zhendong Qin Jiabao Hou Mingjun Lu Jiayi Guo Jinghong Wu Chenyang Wang Xiaoyue Zhu Teng Ma

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Key Points

The research aims to elucidate the regulatory mechanisms of DNA-PKcs in DNA repair processes.
Proposes a 'Spatiotemporal Logic Circuit' model for DNA-PKcs regulation.
Analyzes various post-translational modifications affecting DNA-PKcs function.
Examines structural interfaces for signals related to activation and degradation.
Discusses the implications of targeting DNA-PKcs for therapeutic strategies.
Identifies SUMO-associated interactions stabilizing DNA-PKcs assembly.
Highlights HUWE1-mediated neddylation as a key factor for kinase activation.
Demonstrates K48-linked ubiquitination's role in the turnover of repair complexes.
Addresses challenges posed by the size of DNA-PKcs for therapeutic targeting.

Implication

Research explores DNA-PK regulation mechanisms in double-strand break repair, suggesting new therapeutic insights.

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69c772158bbfbc51511e25d0 https://doi.org/10.3390/biom16040498

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Keep reading

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