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March 28, 2026Biomaterials Science0 citations

ROS-Responsive mPEG–PCL Nanoparticles for Co-Delivery of Paclitaxel Prodrug and R848 in Synergistic Chemo-Immunotherapy

QZQi ZhangHebei Medical UniversityLWLuyao WangJilin UniversityZYZhaofan YangPeking University

Key Points

  • The aim is to enhance antitumor efficacy through the co-delivery of a chemotherapy prodrug and an immune activator.
  • Development of ROS-responsive mPEG–PCL nanoparticles
  • Co-delivery of paclitaxel prodrug and R848
  • Assessment of pharmacokinetics and antitumor efficacy
  • Improved delivery and targeting of therapeutics
  • Enhanced immune activation observed
  • Demonstrated synergy between the chemotherapy and immunotherapy components

Abstract

Chemo-immunotherapy aims to integrate chemotherapy-induced antigen release with innate immune activation to achieve enhanced antitumor efficacy. However, the pharmacokinetic mismatch and systemic toxicity of free small molecules often compromise the...

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69c7722a8bbfbc51511e2604https://doi.org/10.1039/d5bm01811k
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