Undergraduate lab experiment demonstrates effective detection of chlorpromazine in phosphate buffer solution, suggesting a novel method for analysis.
An undergraduate laboratory experiment for inorganic /electroanalytical chemistry is described utilizing an everyday surfactant as a sensor. A cation surfactant Cetyltrimethylammonium Bromide (CTAB) modified carbon paste electrode was fabricated and applied to detection of chlorpromazine (CPZ). CPZ is used in the management of psychotic conditions for patients and it is of primary importance to learn alternative method for detection of CPZ. The Cetyltrimethylammonium Bromide Carbon Paste Electrode (CTABCPE) illustrated reversible behavior by cyclic voltammetry (CV) in the detection of CPZ. The results showed that the electrocatalytic activity of CTAB modified carbon paste electrode (CTABMCPE) was more selective when compared to bare carbon paste electrode (CPE). The modified electrode showed good selectivity, stability and antifouling properties. This lab allowed students to investigate how to build a carbon paste electrode with a capillary tube and modify the electrode surface with a surfactant CTAB to detect CPZ in phosphate buffer solution.
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Chaudhuri et al. (2012) studied this question.
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