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March 28, 2026BMC MedicineOpen Access

Risk classification of internet gaming disorder based on neurobiological subtyping from impulsivity-linked resting-state functional connectivity: a longitudinal design study

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Authors

XWXinwen WenJZJiahao ZhaoZDZhe Du

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Overview

Longitudinal design identifies high-risk subtypes for IGD based on brain connectivity and impulsivity.

Key Points

  • This research aims to classify youth at high risk for internet gaming disorder (IGD) using neurobiological markers linked to impulsivity.
  • Cross-sectional analysis of 770 individuals (642 controls, 128 IGD) to derive impulsivity-anchored resting-state functional connectivity (RSFC) features.
  • Longitudinal discovery cohort of 220 and independent replication cohort of 65 to assess IGD conversion and subtype identification using deep embedded clustering.
  • Evaluation of the link between baseline impulsivity and IGD severity through specific RSFC circuits.
  • High-risk subtype demonstrated significantly higher IGD conversion over 2 years (23.61% vs. 6.76% in discovery; 22.2% vs. 4.3% in replication).
  • Combining impulsivity-linked RSFC outperformed singular models in predicting IGD severity (training r = 0.73, testing r = 0.27).
  • Imbalance in orbitofrontal and occipital RSFC was found to mediate the relationship between impulsivity and future IGD severity.

Cite This Study

Wen et al. (2026) studied this question.

synapsesocial.com/papers/69c7724e8bbfbc51511e2b75https://doi.org/10.1186/s12916-026-04825-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1How impulsivity and sensation seeking drive IGD tendency in healthy young adults: A resting-state MRI study.2025 · 4 citations
  2. 2Association of internet gaming disorder with impulsivity: role of risk preferences2023 · 23 citations
  3. 3Normative Modeling Reveals Functional Connectivity Heterogeneity and Subtypes in Internet Gaming Disorder2025
  4. 4The association between gaming disorder and impulsivity: A systematic review and meta-analysis2025
  5. 5Predictive neural signature of internet gaming disorder severity revealed by cross-network connectivity2026