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This research aims to evaluate the effects of high-speed versus low-speed centrifugation on the quality of platelet-rich fibrin (PRF) preparation.

Comparison between high-speed and low-speed centrifugation concepts for standardizing platelet-rich fibrin preparation to improve reproducibility

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This research compares high-speed and low-speed centrifugation for platelet-rich fibrin preparation, indicating low-speed may enhance quality.

This research aims to evaluate the effects of high-speed versus low-speed centrifugation on the quality of platelet-rich fibrin (PRF) preparation.
Eighty healthy volunteers were divided into two groups for PRF preparation.
Two centrifugation protocols were used: high-speed (2400 rpm) and low-speed (1200 rpm) for 10 minutes each.
PRF clots were analyzed for macroscopic and histological features, cellular counts, and growth factor concentrations.
Low-speed centrifugation resulted in higher concentrations of cellular components compared to high-speed.
PRF prepared using low-speed had greater levels of vascular endothelial growth factor and transforming growth factor β1.
Overall, low-speed centrifugation produced a better quality PRF compared to high-speed.

Eldesoukey et al. (2026) studied this question.

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This research compares high-speed and low-speed centrifugation for platelet-rich fibrin preparation, indicating low-speed may enhance quality.