A review demonstrates techniques for collecting rotation data in chiral compounds, enhancing understanding of stereochemistry concepts.
Stereochemistry and chirality are part of the canon of the sophomore organic chemistry sequence. Usually, in the first semester of the lecture sequence, students learn about enantiomers, diastereomers, polarimetry, optical activity, and meso compounds. The described exercise provides the students with an opportunity to actually collect rotation data for a variety of chiral compounds thus making more concrete the terms and relationships previously described in lecture. Additionally, students are required to use laboratory skills learned previously (solution preparation) as well as add to their growing repertoire of experience with analytical instruments (use of the polarimeter).
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Carpenter et al. (2007) studied this question.
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