Discovery-based protocol demonstrates effective coupling in aqueous media, suggesting a green chemistry approach.
A discovery-based general and efficient protocol for the palladium-catalyzed ligand-free aerobic Suzuki-Miyaura coupling reaction in aqueous media had been developed for the undergraduate advanced organic chemistry laboratory. The highlight of the experiment is the synthesis of an important AT2 receptor antagonist intermediate, 2-cyano-4'-methylbiphenyl, along with other biphenyl derivatives. The experiment explored an efficient green SM coupling reaction in aqueous media. The Pd(OAc)2/(i-Pr)2 NH/H2O system showed very good catalytic activity and also found to be versatile for the coupling of substituted bromobenzenes and arylboronic acids.
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Dineshkumar et al. (2019) studied this question.
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