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Laboratory experiment measures ibuprofen in expired tablets using HPLC and UV-VIS, indicating quality assessment after expiration.
In this laboratory experiment, high-performance liquid chromatography (HPLC) and ultraviolet-visible (UV-VIS) spectroscopy are used to measure expired and unexpired over-the-counter ibuprofen tablets. The laboratory, which is appropriate for an upper-level analytical chemistry course, introduces students to HPLC and addresses an interesting question from everyday life. Ultraviolet-visible (UV-VIS) spectroscopy is also performed on the same samples, and results are compared. The use of an instrumentation amplifier and Vernier software with legacy instrumentation is also described.
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Dong et al. (2014) studied this question.
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