This laboratory experiment investigates linear free energy relationships between Hammett σ+ parameters and the 1H-NMR chemical shifts of substituted benzhydrol reagents. The significance of resonance and field effects on proton shielding can be determined by relating chemical shift data to various forms of Hammett equations. Benzhydrylium cations can be studied as well by 13C-NMR spectroscopy.
No takes yet. Share an insight, caveat, or question.
Parsons et al. (2012) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: