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March 28, 2026Open Access

Experimental infection and viral pathogenesis of a human isolate of H5N1 highly pathogenic avian influenza strain in Jersey cows

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Authors

FFFlavio Cargnin FaccinLGL. Claire GayDRDikshya Regmi

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Overview

Experimental infection shows H5N1 susceptibility and impacts milk production in Jersey cows, suggesting their value in studying disease mechanisms.

Key Points

  • To investigate the susceptibility of Jersey cows to H5N1 infection and its effects on milk production and pathology.
  • Inoculated three Jersey lactating cows intranasally and intramammarily with H5N1 virus
  • Monitored milk production changes post-inoculation
  • Collected milk and swabs for viral RNA detection
  • Milk production rapidly decreased after inoculation
  • Milk samples showed a colostrum-like appearance
  • High levels of viral RNA were found in teats and milk samples
  • Low levels of viral RNA were detected in the respiratory tract

Cite This Study

Faccin et al. (2026) studied this question.

synapsesocial.com/papers/69c772d98bbfbc51511e34cchttps://doi.org/10.1038/s44433-025-00002-5
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