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March 28, 2026European Journal of Organic Chemistry

Rhodium‐Catalyzed Cascade Annulation of N ‐Nitrosoanilines With Trifluoromethyl‐Imidoyl Sulfoxonium Ylides for the Synthesis of Trifluoromethyl‐Functionalized Indazole N ‐Oxides

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Authors

YLYang LiCCChun Cai

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Overview

Cascade annulation synthesizes trifluoromethyl-indazole N-oxides, highlighting practical applications.

Key Points

  • The research aims to develop an efficient method for synthesizing trifluoromethyl-functionalized indazole N-oxides.
  • Utilized Rh(III)-catalyzed C–H activation combined with [4 + 1] annulation.
  • Conducted reactions at room temperature under air atmosphere.
  • Incorporated diverse substituents using N-nitrosoanilines and sulfoxonium ylides.
  • Assessed scalability and functional group tolerance in reactions.
  • Achieved synthesis of indazole N-oxides via C–H activation at ambient temperature.
  • Demonstrated high functional group tolerance and substrate scalability.
  • Highlighted potential for large-scale production with gram-scale experiments.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69c772d98bbfbc51511e352bhttps://doi.org/10.1002/ejoc.70428
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