November 18, 2024Journal of the American College of Cardiology56 citationsOpen Access
View Full PaperAortic Valve Replacement vs Clinical Surveillance in Asymptomatic Severe Aortic Stenosis
Structured PICO
Does early aortic valve replacement reduce hospitalization, stroke, and mortality in patients with asymptomatic severe aortic stenosis compared to clinical surveillance?
P
Population
Patients with asymptomatic severe aortic stenosis (meta-analysis of 4 RCTs)
I
Intervention
Early aortic valve replacement (AVR)
C
Comparator
Clinical surveillance (CS)
O
Outcome
Unplanned cardiovascular or heart failure hospitalization, stroke, all-cause mortality, and cardiovascular mortalityhard clinical
Early aortic valve replacement in asymptomatic severe aortic stenosis reduces unplanned cardiovascular and heart failure hospitalizations as well as stroke, though it does not significantly impact mortality compared to clinical surveillance.
Abstract
In this meta-analysis of 4 RCTs, early AVR was associated with a significant reduction in unplanned cardiovascular or HF hospitalization and stroke and no differences in all-cause and cardiovascular mortality compared with CS.