c-Myc expression in cardiac fibroblasts and myocytes is essential for cardiac angiogenesis, highlighting a potential therapeutic target for cardiac remodeling.
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Suggests c-Myc as potential target for cardiac angiogenesis; animal data leaves human therapeutic application open.
These data demonstrate that proper c-Myc expression in cardiac fibroblasts and myocytes is essential to cardiac angiogenesis. These results have the potential for novel therapeutic applications involving the angiogenic response during cardiac remodeling.
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Souders et al. (2012) studied this question.
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