January 1, 1994Journal of Cellular Biochemistry

c‐myc Gene expression is localized to the myocyte following hemodynamic overload in vivo

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Population

Cats with right ventricular overload induced by pulmonary artery banding

Design

Preclinical

Follow-up

1 month

Authors

PPPia S. PollackAstraZeneca (United States)SHSteven R. HouserSteven Winter Associates (United States)RBRicardo BudjakTemple University

Discussion

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Implication

Animal data support c-myc in hypertrophy response; leaves open therapeutic targeting in human disease.

Structured PICO

Population

Cats with right ventricular overload induced by pulmonary artery banding

Intervention

Pulmonary artery banding to induce right ventricular overload

Outcome

Expression of c-myc and alpha-skeletal actin mRNA, and localization of immunoreactive Myc proteinsurrogate

Hemodynamic overload upregulates c-myc gene expression localized to right ventricular myocyte nuclei in a large animal model, supporting its role in the general response to cardiac hypertrophy.

Cite This Study

Pollack et al. (1994) studied this question.

synapsesocial.com/papers/6a91979aae2c4ed52ef13b7e https://doi.org/10.1002/jcb.240540109

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c‐myc Gene expression is localized to the myocyte following hemodynamic overload in vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

c‐myc Gene expression is localized to the myocyte following hemodynamic overload in vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider