January 1, 1988Proceedings of the National Academy of SciencesOpen Access

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

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Population

136 Wistar rats, including normal developmental stages, and adult males subjected to abdominal aortic…

Comparison

Pressure overload induced by abdominal or… vs Sham-operated animals and normal developmental…

Design

Preclinical

Follow-up

Up to 12 weeks

Authors

SISeigo IzumoHeart Failure & Transplant BNB Nadal-GinardKing's College London VMVijak MahdaviBoston Children's Hospital

Discussion

Member takes

Implication

Highlights rapid gene reprogramming as potential hypertrophy trigger; leaves open whether these pathways are therapeutic targets in human disease.

Structured PICO

Population

136 Wistar rats, including normal developmental stages (20-day-old fetuses n=30, 2-day-old neonates n=30, adults n=8), and adult males subjected to abdominal aortic coarctation (n=28), ascending aortic coarctation (n=12), sham operation (n=12), hyperthyroidism (n=8), or hypothyroidism (n=8).

Intervention

Pressure overload induced by abdominal or ascending aortic coarctation.

Comparator

Sham-operated animals and normal developmental controls.

Outcome

Expression levels of cellular protooncogenes (c-fos, c-myc), heat shock protein (hsp70), fetal contractile protein isogenes (alpha-actin, sarcomeric tropomyosin), and atrial natriuretic factor (ANF) mRNA in the ventricular myocardium.surrogate

Hemodynamic pressure overload triggers a rapid, sequential reprogramming of cardiac gene expression, beginning with protooncogenes and stress proteins, followed by the re-induction of fetal contractile genes and ANF.

Limitations

Uncertainty whether accumulation of smooth- and nonmuscle B-tropomyosin mRNA occurs only in cardiac myocytes or is also due to fibroblast proliferation

Cite This Study

Izumo et al. (1988) studied this question.

synapsesocial.com/papers/6a1008ead13714ec96ff08cd https://doi.org/10.1073/pnas.85.2.339

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Implication

Highlights rapid gene reprogramming as potential hypertrophy trigger; leaves open whether these pathways are therapeutic targets in human disease.

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider