Key result
Stress conditions including anesthesia, thoracotomy, and aortic stenosis induced HSP70 and c-Fos expression in myocardial muscle and nonmuscle cells of adult rats.
Population
Rat hearts during ontogenic development and under stress conditions associated with pressure overload
Comparison
Stress conditions vs Baseline/developmental stages without stress
Design
Preclinical
Follow-up
3 hours following anesthesia
Authors
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Hypothesis-generating in rodent hypertrophy models; leaves open human relevance and clinical translation.
The expression of HSP70, c-Fos, and c-Myc in cardiac muscle and nonmuscle cells differs and depends on specific triggers such as developmental stage and stress conditions.
Snoeckx et al. (1991) studied Cardiac development and stress conditions. Stress conditions (anesthesia, thoracotomy, aortic stenosis) was evaluated on Expression and cellular distribution of HSP70, c-Fos, and c-Myc. Stress conditions including anesthesia, thoracotomy, and aortic stenosis induced HSP70 and c-Fos expression in myocardial muscle and nonmuscle cells of adult rats.
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