Highlights a strong link between cyanotic congenital heart disease and pheochromocytoma/paraganglioma, suggesting a need for further investigation into the underlying mechanisms.
May warrant clinical vigilance in CCHD; leaves open prospective validation and mechanistic studies.
There is a strong link between CCHD and PHEO-PGL. Whether these rare diseases coassociate due to hypoxic stress, common genetic or developmental factors, or some combination requires further investigation.
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Opotowsky et al. (2015) studied this question.
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