Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy

Ming Li; Ling Wang; Dianchun Shi; Jia Nee Foo; Zhong Zhong; Chiea Chuen Khor; Chiara Lanzani; Lorena Citterio; Erika Salvi; Peiran Yin; Jin‐Xin Bei; Li Wang; Yunhua Liao; Jian Chen; Qinkai Chen; Gang Xu; Gengru Jiang; Jianxin Wan; Menghua Chen; Nan Chen; Hong Zhang; Yi‐Xin Zeng; Zhihong Liu; Jianjun Liu; Xueqing Yu

doi:10.1681/asn.2019080799

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Abstract

A meta-analysis of GWAS data revealed three novel genetic risk loci for IgAN, and three HLA polymorphisms and two SNPs within the MHC region, and demonstrated the genetic heterogeneity of seven loci out of 24 confirmed risk SNPs. These variants may explain susceptibility differences between Chinese and European populations.

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Li et al. (2020) studied this question.

synapsesocial.com/papers/69c88b598c5c782ac5fa8f34 https://doi.org/10.1681/asn.2019080799

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Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy

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Abstract

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Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy

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Abstract

Discussion

Cite This Study

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