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March 29, 2026Frontiers in MicrobiologyOpen Access

Eucommia polysaccharides alleviate experimental colitis by reshaping colonic microbiota composition, metabolites, and modulating the IL-17 signaling pathway

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Authors

WYWenna YaoMongolian University of Life SciencesSYShuo YanInner Mongolia Agricultural UniversityRDRuilin DuInner Mongolia Agricultural University

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Implication

Experimental study reveals that Eucommia polysaccharides reduce colitis symptoms in mice by changing gut bacteria and metabolites, indicating a new treatment approach for ulcerative colitis.

Key Points

  • The study aims to evaluate the efficacy of Eucommia polysaccharides in alleviating colitis through microbiota and metabolic modulation.
  • Administered low and high doses of Eucommia polysaccharides to mice after fecal microbiota transplantation.
  • Induced colitis in mice using dextran sulfate sodium for comparison.
  • Analyzed changes in gut microbiota composition, colonic health, and relevant metabolites.
  • Examined correlations between bile acids and IL-17 signaling pathway genes.
  • High-dose Eucommia polysaccharides significantly improved colitis symptoms.
  • Restored gut microbial diversity and reduced harmful bacteria.
  • Enhanced bile secretion pathways, especially involving deoxycholic and hyodeoxycholic acids.
  • Found negative correlations between these bile acids and harmful gut bacteria.

Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/69c8c115de0f0f753b39ba2ahttps://doi.org/10.3389/fmicb.2026.1769429
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