Cancer in Childhood, Adolescence, or Young Adulthood and Risk of Congenital Malformations and Chromosomal Abnormalities in Children: A Matched Cohort Study and Descriptive Pooled Analysis

March 1, 2026EJC Paediatric OncologyOpen Access

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This research aims to evaluate the risk of congenital malformations and chromosomal abnormalities in children of cancer survivors.
Analyzed children born in Sweden from 2006-2018.
Compared children with cancer survivor parents to matched unexposed children.
Measured outcomes using ICD-10 Q-codes for congenital issues.
Calculated odds ratios adjusting for various parental factors.
Pooled relative risks from existing studies using a random-effects model.
No significant difference in malformation rates: 11.9% in exposed vs. 11.8% in unexposed children.
Adjusted odds ratio of 1.01 indicates no increased risk overall.
Pooled analysis suggested a slight risk increase in children by parental cancer diagnosis, but results may be confounded.

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Matched cohort study assesses congenital malformations in children of cancer survivors, suggesting limited risk.

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Henning et al. (2026) studied this question.

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